WNT signalling pathways as therapeutic targets in cancer

@article{Anastas2012WNTSP,
  title={WNT signalling pathways as therapeutic targets in cancer},
  author={Jamie N. Anastas and Randall T. Moon},
  journal={Nature Reviews Cancer},
  year={2012},
  volume={13},
  pages={11-26}
}
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery… 
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