WNT signalling in the immune system: WNT is spreading its wings

@article{Staal2008WNTSI,
  title={WNT signalling in the immune system: WNT is spreading its wings},
  author={Frank J T Staal and Tiago Cunha Lu{\'i}s and Machteld M. Tiemessen},
  journal={Nature Reviews Immunology},
  year={2008},
  volume={8},
  pages={581-593}
}
WNT proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. In blood and immune cells, WNT signalling controls the proliferation of progenitor cells and might also affect the cell-fate decisions of stem cells. Recent studies indicate that WNT proteins also regulate effector T-cell development, regulatory T-cell activation… CONTINUE READING
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