WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo


A regulatory loop between the fibroblast growth factors FGF-8 and FGF-10 plays a key role in limb initiation and AER induction in vertebrate embryos. Here, we show that three WNT factors signaling through beta-catenin act as key regulators of the FGF-8/FGF-10 loop. The Wnt-2b gene is expressed in the intermediate mesoderm and the lateral plate mesoderm in… (More)
DOI: 10.1016/S0092-8674(01)00285-9

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