WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways


Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 induced de-differentiation of human articular chondrocytes through simultaneous activation of β-catenin-dependent and independent responses. WNT-3A activates both the β-catenin-dependent… (More)
DOI: 10.1083/jcb.201011051


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