WNT/Frizzled-2 Signaling Induces Aggregation and Adhesion among Cardiac Myocytes by Increased Cadherin–β-Catenin Complex

@article{Toyofuku2000WNTFrizzled2SI,
  title={WNT/Frizzled-2 Signaling Induces Aggregation and Adhesion among Cardiac Myocytes by Increased Cadherin–β-Catenin Complex},
  author={Toshihiko Toyofuku and Zhang Yan Hong and Tsunehiko Kuzuya and Michihiko Tada and Masatsugu Hori},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={225 - 242}
}
Wingless is known to be required for induction of cardiac mesoderm in Drosophila, but the function of Wnt family proteins, vertebrate homologues of wingless, in cardiac myocytes remains unknown. When medium conditioned by HEK293 cells overexpressing Wnt-3a or -5a was applied to cultured neonatal cardiac myocytes, Wnt proteins induced myocyte aggregation in the presence of fibroblasts, concomitant with increases in beta-catenin and N-cadherin in the myocytes and with E- and M-cadherins in the… CONTINUE READING

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Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development

  • M. A. Torres, J. A. Yang Snyder, S. M. Purcell, A. A. DeMarais, L. L. McGrew, R. T. Moon.
  • J. Cell Biol. 133:1123–1137.
  • 1996
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