Corpus ID: 16885214

WNT/FZD Signaling: An Odyssey from Molecular Pharmacology to Brain (Patho)Physiology

@inproceedings{Dijksterhuis2015WNTFZDSA,
  title={WNT/FZD Signaling: An Odyssey from Molecular Pharmacology to Brain (Patho)Physiology},
  author={J. P. Dijksterhuis},
  year={2015}
}
The 19 members of the lipoglycoprotein family of WNTs interact with the highly conserved cysteine-rich domain (CRD) of ten members of the Frizzled (FZD1-10) family. The seven transmembrane-spanning surface receptors are listed as G protein-coupled receptors and are known to interact with heterotrimeric G proteins as well as the scaffolding protein disheveled. Upon ligand binding, activation of β-catenin-dependent and/or –independent pathways are induced. The WNT/Frizzled signaling pathway is… Expand

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