WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.

@article{Leung2016WNTcateninSM,
  title={WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.},
  author={Alan W. Leung and Barbara Murdoch and Ahmed F. Salem and Maneeshi S. Prasad and Gustavo Adolfo Gomez and Mart{\'i}n I Garc{\'i}a-Castro},
  journal={Development},
  year={2016},
  volume={143 3},
  pages={
          398-410
        }
}
Neural crest (NC) cells arise early in vertebrate development, migrate extensively and contribute to a diverse array of ectodermal and mesenchymal derivatives. Previous models of NC formation suggested derivation from neuralized ectoderm, via meso-ectodermal, or neural-non-neural ectoderm interactions. Recent studies using bird and amphibian embryos suggest an earlier origin of NC, independent of neural and mesodermal tissues. Here, we set out to generate a model in which to decipher signaling… CONTINUE READING

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