WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.

@article{Zhuang2011WNK4KI,
  title={WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.},
  author={Jieqiu Zhuang and Xuemei Zhang and Dexuan Wang and Juan Jenny Li and Bo Zhou and Z. Y. Shi and Dingying Gu and Donald D. Denson and Douglas C. Eaton and Hui Cai},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={301 2},
  pages={F410-9}
}
WNK [with no lysine (k)] kinase is a serine/threonine kinase subfamily. Mutations in two of the WNK kinases result in pseudohypoaldosteronism type II (PHA II) characterized by hypertension, hyperkalemia, and metabolic acidosis. Recent studies showed that both WNK1 and WNK4 inhibit ROMK activity. However, little is known about the effect of WNK kinases on Maxi K, a large-conductance Ca(2+) and voltage-activated potassium (K) channel. Here, we report that WNK4 wild-type (WT) significantly… CONTINUE READING
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