WNK3 is a putative chloride-sensing kinase.

  title={WNK3 is a putative chloride-sensing kinase.},
  author={Diana Pacheco-{\'A}lvarez and Gerardo Gamba},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={28 6},
The with-no-lysine kinase 3 (WNK3) is a serine/threonine kinase that modulates the activity of the electroneutral cation-coupled chloride cotransporters (CCC). Using the Xenopus laevis oocyte heterologous expression system, it has been shown that WNK3 activates the Na(+)-coupled chloride cotransporters NKCC1, NKCC2, and NCC and inhibits the K(+)-coupled chloride cotransporters KCC1 through KCC4. Interestingly, the effect of catalytically inactive WNK3 is opposite to that of wild type WNK3… CONTINUE READING


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Regulation of the NKCC 2 ion cotransporter by SPAK - OSR 1 - dependent and - independent pathways

  • C Richardson, K Sakamoto, +4 authors DR Alessi
  • J Cell Sci
  • 2011

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