WNK3-SPAK Interaction is Required for the Modulation of NCC and other Members of the SLC12 Family

@article{Pachecolvarez2012WNK3SPAKII,
  title={WNK3-SPAK Interaction is Required for the Modulation of NCC and other Members of the SLC12 Family},
  author={Diana Pacheco-{\'A}lvarez and Norma V{\'a}zquez and Mar{\'i}a Casta{\~n}eda-Bueno and Paola de-los-Heros and C{\'e}sar Cortes-Gonz{\'a}lez and Erika Moreno and Patricia Meade and Norma A. Bobadilla and Gerardo Gamba},
  journal={Cellular Physiology and Biochemistry},
  year={2012},
  volume={29},
  pages={291 - 302}
}
The serine/threonine with no lysine kinase 3 (WNK3) modulates the activity of the electroneutral cation-coupled chloride cotransporters (CCC) to promote Cl- influx and prevent Cl- efflux, thus fitting the profile for a putative “Cl--sensing kinase”. The Ste20-type kinases, SPAK/OSR1, become phosphorylated in response to reduction in intracellular chloride concentration and regulate the activity of NKCC1. Several studies have now shown that WNKs function upstream of SPAK/OSR1. This study was… CONTINUE READING

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With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.

  • American journal of physiology. Cell physiology
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND

WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter.

  • American journal of physiology. Renal physiology
  • 2014
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CITES BACKGROUND & METHODS

Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse.

  • American journal of physiology. Renal physiology
  • 2013
VIEW 13 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.

  • American journal of physiology. Renal physiology
  • 2012
VIEW 3 EXCERPTS
CITES BACKGROUND

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