WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).

@article{Leng2006WNK3AK,
  title={WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).},
  author={Qiang Leng and Kristopher Thomas Kahle and Jesse Rinehart and Gordon G Macgregor and Frederick H. Wilson and Cecilia M. Canessa and Richard P. Lifton and Steven C. Hebert},
  journal={The Journal of physiology},
  year={2006},
  volume={571 Pt 2},
  pages={275-86}
}
The serine-threonine kinase WNK3 modulates Cl- transport into and out of cells through its regulation of SLC12A cation/Cl- cotransporters, implicating it as (one of) the long-sought Cl-/volume-sensitive kinase(s). Integrators in homeostatic systems regulate structurally diverse but functionally coupled elements. For example, the related kinase WNK4 regulates the Na-Cl co-transporter (NCC), paracellular Cl- flux, and the K+ channel ROMK1 (Kir1.1) to maintain renal NaCl and K+ homeostasis… CONTINUE READING