WNK1 kinase balances T cell adhesion versus migration in vivo

  title={WNK1 kinase balances T cell adhesion versus migration in vivo},
  author={Robert K{\"o}chl and F. Thelen and Lesley Vanes and Tiago F Braz{\~a}o and Kathryn Fountain and Jian Xie and C L Huang and Ruth Lyck and Jens V. Stein and Victor L. J. Tybulewicz},
  booktitle={Nature Immunology},
Adhesion and migration of T cells are controlled by chemokines and by adhesion molecules, especially integrins, and have critical roles in the normal physiological function of T lymphocytes. Using an RNA-mediated interference screen, we identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration. We found that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and… CONTINUE READING
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