WNK1 and WNK4 modulate CFTR activity.

  title={WNK1 and WNK4 modulate CFTR activity.},
  author={Chao-Ling Yang and Xuehong Liu and Alex Paliege and Xiaoman Zhu and Sebastian Bachmann and David C. Dawson and David H Ellison},
  journal={Biochemical and biophysical research communications},
  volume={353 3},
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-gated chloride channel. WNK kinases are widely expressed modulators of ion transport. WNK1 and WNK4, two WNK kinases that are mutated in familial hyperkalemic hypertension (FHHt), are co-expressed with CFTR in several organs, raising the possibility that WNK kinases might alter CFTR activity in vivo or that CFTR could be involved in the pathogenesis of FHHt. Here, we report that WNK1 co-localizes with CFTR protein in… CONTINUE READING


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