WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension

Abstract

ABSTRACTThe WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. This… (More)
DOI: 10.1038/sj.cr.7290256

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