WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension


ABSTRACTThe WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. This… (More)
DOI: 10.1038/sj.cr.7290256


4 Figures and Tables


Citations per Year

117 Citations

Semantic Scholar estimates that this publication has 117 citations based on the available data.

See our FAQ for additional information.