WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters.

@article{Kahle2006WNKPK,
  title={WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters.},
  author={Kristopher T. Kahle and Jesse Rinehart and Aaron M. Ring and Ignacio Gim{\'e}nez and Gerardo Gamba and Steven C. Hebert and Richard P Lifton},
  journal={Physiology},
  year={2006},
  volume={21},
  pages={
          326-35
        }
}
Precise control of cellular Cl(-) transport is necessary for many fundamental physiological processes. For example, the intracellular concentration of Cl(-), fine-tuned through the coordinated action of cellular Cl(-) influx and efflux mechanisms, determines whether a neuron's response to GABA is excitatory or inhibitory. In epithelia, synchrony between apical and basolateral Cl(-) flux, and transcellular and paracellular Cl(-) transport, is necessary for efficient transepithelial Cl… 
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