WNK kinases, renal ion transport and hypertension.

  title={WNK kinases, renal ion transport and hypertension.},
  author={Pedro San-Cristobal and P de los Heros and Jos{\'e} Ponce-Coria and Erika Moreno and Gerardo Gamba},
  journal={American journal of nephrology},
  volume={28 5},
Two members of a recently discovered family of protein kinases are the cause of an inherited disease known as pseudohypoaldosteronism type II (PHAII). These patients exhibit arterial hypertension together with hyperkalemia and metabolic acidosis. This is a mirror image of Gitelman disease that is due to inactivating mutations of the SLC12A3 gene that encodes the thiazide-sensitive Na(+):Cl(-) cotransporter. The uncovered genes causing PHAII encode for serine/threonine kinases known as WNK1 and… CONTINUE READING
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