3 Citations
Glioblastoma Stem Cells and Withaferin A, A Review
- MedicineBiomedical Journal of Scientific & Technical Research
- 2019
Glioblastoma multiforme is characterized by tumor cell
heterogeneity, and by recurrent invasive tumors following
conventional radiation, cytotoxic drugs, and limited ablative
surgery [1-5]...
Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives
- MedicineJournal of Natural Medicines
- 2016
Withaferin A (WA), utilized in Ayurvedic medicine for centuries, is attracting attention for its antitumor capabilities and is relatively nontoxic and has shown potential in crossing the blood–brain barrier.
Withaferin A and its potential role in glioblastoma (GBM)
- MedicineJournal of Neuro-Oncology
- 2016
This review focuses on the use of Withaferin A alone, or in combination with other treatments, as a newer option for therapy against the most aggressive variant of brain tumors, Glioblastoma.
References
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MGMT methylation predicts the clinical response of primary gliomas to first-line chemotherapy with the alkylating agent temozolomide, and may open up possibilities for more customized treatments of human brain tumors.
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
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Enhancement of radiation induced cell death in chicken B lymphocytes by withaferin A.
- Biology, MedicineIndian journal of experimental biology
- 2008
Inhibition of DNA repair is further indicated in a significant decrease in surviving fraction of DT40 cells by post-irradiation incubation with WA, suggesting that WA enhances radiosensitivity by interfering with homologous repair, the major pathway of DSB repair in these cells.
Wnt/beta-Catenin Signaling and Small Molecule Inhibitors
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The broad implications of Wnt/β-catenin signaling in development, in the adult body and in disease render the pathway a prime target for pharmacological research and development.
Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition*
- Biology, ChemistryThe Journal of Biological Chemistry
- 2010
This study suggests that activation of AMPK by TMZ contributes to glioblastoma cell apoptosis, probably by promoting p53 activation and inhibiting mTORC1 signaling.
Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone
- Biology, ChemistryThe AAPS Journal
- 2013
Cancer-protective role for WA has now been established using chemically-induced and oncogene-driven rodent cancer models, and key in vivo preclinical studies demonstrating anticancer effects of WA are summarized.
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
- BiologyApoptosis
- 2008
Findings suggest that p38MAPK in leukemic cells promotes WA-induced apoptosis, and therefore WA holds promise as a new, alternative, inexpensive chemotherapeutic agent for the treatment of patients with leukemia of both lymphoid and myeloid origin.
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A physical interaction between CDC37 and CDK4 suggests that CDC37 may regulate the mammalian cell cycle through a direct effect onCDK4, a cyclin D-dependent kinase that controls progression through G1 of the mammal cell cycle.
Functional Interaction of Human Cdc37 with the Androgen Receptor but Not with the Glucocorticoid Receptor*
- BiologyThe Journal of Biological Chemistry
- 2001
The results show that Cdc37 binds to AR but not to glucocorticoid receptors (GR) synthesized in rabbit reticulocyte lysates, strengthening the notion that CDC37 has a wider range of polypeptide clients than was realized previously.
Challenges in drug delivery to tumors of the central nervous system: an overview of pharmacological and surgical considerations.
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