WIRKUNGSBEDINGUNGEN VON BLAUSÄURE UND SCHWEFELWASSERSTOFF UND MOGLICHKEITEN DER VERGIFTUNGSBEHANDLUNG

@article{Lendle1964WIRKUNGSBEDINGUNGENVB,
  title={WIRKUNGSBEDINGUNGEN VON BLAUS{\"A}URE UND SCHWEFELWASSERSTOFF UND MOGLICHKEITEN DER VERGIFTUNGSBEHANDLUNG},
  author={Ludwig Lendle},
  journal={Japanese Journal of Pharmacology},
  year={1964},
  volume={14},
  pages={215-224}
}
  • L. Lendle
  • Published 1964
  • Chemistry
  • Japanese Journal of Pharmacology
Blausaure und Schwefelwasserstoff wirken, wenn sic gasformig inhaliert werden auBerordentlich schnell and beide sind hochtoxische Verbindungen mit einer Wirkun in etwa der gleichen GroBenordnung. Vergiftungen mit beiden Stoffen sind in gewissen Industriezweigen sehr gefurchtet, so z.B. die Blausaure in der Metallurgic and in der Kunststoffproduktion; der Schwefelwasserstoff hat neuerdings auch bei Erdolbohrungen wichtige Vergiftungsmoglichkeiten geboten. Das Wesen der Blausaurevergiftung gilt… Expand
12 Citations
Die Bedeutung der Wirkungsgeschwindigkeit von Antidoten bei der Behandlung der BlausÄurevergiftung
TLDR
It could be demonstrated in guinea pigs that cobaltous compounds as aquocobalamine, Co2-EDTA and cobalt desferrioxamine are by far superior to traditional antidotes as sodium nitrite and sodium thiosulfate and in an optimal dose range there was hardly a difference in the efficiency of these complex cobALTous compounds. Expand
The role of cyanide liberation in the acute toxicity of aliphatic nitriles.
TLDR
The results suggested that the other nitriles examined here possess little, if any, acute toxicity in the absence of normal hepatic function and that these nit riles were activated by hepatic mechanisms to release cyanide which can account for their major acute toxic effects. Expand
The efficiency of aquocobalamine as an antidote in cyanide poisoning when given alone or combined with sodium thiosulfate
TLDR
The combination of the antidotes aquocobalamine and thiosulfate proved to possess high rate of reaction and a large detoxifying capacity in guinea pigs and cats and in cats with antidote doses of 200 mg/kg aquOCobalamine combined with 500 mg/ kg thios sulfurate. Expand
Comparative toxicities of aliphatic nitriles.
TLDR
Toxic expression of aliphatic nitriles depends not only upon cyanide release but also on their degree of unsaturation, which plays a minimal role in their toxicity. Expand
Estimation of the convulsive effect of cyanide in rats.
  • G. Cassel
  • Chemistry, Medicine
  • Pharmacology & toxicology
  • 1995
TLDR
Changes in dopamine appear to be dependent on convulsions, as rats infused with cyanide at the optimal dose rate showed increased striatal dopamine levels, while animals infused with the threshold dose did not show any significant changes in noradrenaline or in dopamine metabolites. Expand
COBALT COMPOUNDS AS ANTIDOTES FOR HYDROCYANIC ACID.
  • C. Evans
  • Chemistry, Medicine
  • British journal of pharmacology and chemotherapy
  • 1964
TLDR
The antidotal potency of a cobalt salt (acetate), of dicobalt edetate, of hydroxocobalamin and of cobinamide against hydrocyanic acid was examined mainly on mice and rabbits, which found that the oxygen uptake of the body is rapidly reinstated when one of the cobalt antidotes has been successfully administered. Expand
Inhalation toxicology of acute exposure to aliphatic nitriles.
TLDR
Pretreatment with Na2S2O3 or NaNO2, two common inorganic cyanide antagonists, can provide significant (p < 0.05) protection against the mortality associated with exposure to lethal concentrations of these nitriles. Expand
Congenital malformations induced by infusion of sodium cyanide in the golden hamster.
TLDR
It is concluded that cyanide is teratogenic over a narrow range of dose rates, and malformations produced by cyanide were similar to those produced by a variety of cyanogenic compounds including aliphatic nitriles and amygdalin. Expand
Acetonitrile serum concentrations and cyanide blood levels in a case of suicidal oral acetonitrile ingestion.
TLDR
A case of suicidal oral acetonitrile ingestion of about 5 mL without severe symptoms of intoxication in a previously healthy adult male with a body weight of 60 kg is reported. Expand
A critical review of the literature on hydrogen sulfide toxicity.
TLDR
This review of the literature is intended as an evaluative report rather than an annotated bibliography of all the source material examined on hydrogen sulfide, noting information gaps that may require further investigation. Expand
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