WIP1 phosphatase at the crossroads of cancer and aging.

Abstract

The PP2C family serine/threonine phosphatase WIP1 is characterized by distinctive oncogenic properties mediated by inhibitory functions on several tumor suppressor pathways, including ATM, CHK2, p38MAPK and p53. PPM1D, the gene encoding WIP1, is aberrantly amplified in different types of human primary cancers, and its deletion in mice results in a profound… (More)
DOI: 10.1016/j.tibs.2009.09.005

Topics

  • Presentations referencing similar topics