WIP null mice display a progressive immunological disorder that resembles Wiskott-Aldrich syndrome.

@article{Curcio2007WIPNM,
  title={WIP null mice display a progressive immunological disorder that resembles Wiskott-Aldrich syndrome.},
  author={Claudia Curcio and Tania Pannellini and Stefania Lanzardo and Guido Forni and Piero Musiani and In{\'e}s Mar{\'i}a Ant{\'o}n},
  journal={The Journal of pathology},
  year={2007},
  volume={211 1},
  pages={67-75}
}
The Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency syndrome caused by mutations in the WAS protein (WASP). This participates in signalling and cytoskeletal homoeostasis, and some of its activities are regulated by its binding to the WASP interacting protein (WIP). WIP deficiency, however, has not yet been shown to be of pathological significance in humans. Here we show that, in WIP null (WIP(-/-)) mice, it produces haematological alterations and anatomical abnormalities in… CONTINUE READING
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