WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer.

@article{Wissmann2003WIF1AC,
  title={WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer.},
  author={Christoph Wissmann and Peter J. Wild and S. L{\"o}ffler Kaiser and Stefan Roepcke and Robert Franz St{\"o}hr and Matthias Woenckhaus and Glen Kristiansen and Jen-Chih Hsieh and Ferdinand Hofstaedter and Arndt Hartmann and Ruth Knuechel and Andr{\'e} Rosenthal and Christian Pilarsky},
  journal={The Journal of pathology},
  year={2003},
  volume={201 2},
  pages={204-12}
}
To detect novel Wnt-pathway genes involved in tumourigenesis, this study analysed the RNA expression levels of 40 genes of the Wnt pathway by chip hybridization of microdissected matched pairs of 54 primary prostate carcinomas. Eleven genes showed greater than two-fold differential expression in at least 10% of prostate cancers. Three of these genes encode extracellular components of the Wnt pathway (WNT2, WIF1, SFRP4); two are receptors (FZD4, FZD6); two belong to the intracellular signal… CONTINUE READING
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