Stability, Bifurcation, and a Pair of Conserved Quantities in a Simple Epidemic System with Reinfection for the Spread of Diseases Caused by Coronaviruses
- MathematicsDiscrete Dynamics in Nature and Society
In this paper, we study a modified SIRI model without vital dynamics, based on a system of nonlinear ordinary differential equations, for epidemics that exhibit partial immunity after infection,…
A machine learning regression model for the screening and design of potential SARS-CoV-2 protease inhibitors
- BiologyNetw. Model. Anal. Health Informatics Bioinform.
A machine learning model that can predict the binding free energies of compounds to the SARS-CoV-2 main protease is presented, which can help conserve and maximize available resources by limiting biological assays to compounds that yielded favorable outcomes from the model.
COVID-19: breaking down a global health crisis
- MedicineAnnals of clinical microbiology and antimicrobials
The impact of the virus on a global, micro to macro scale is synthesized and therapy with dexamethasone, remdesivir, and tocilizumab appear to be most promising to date.
COVID-19: A review of the proposed pharmacological treatments
- Medicine, BiologyEuropean Journal of Pharmacology
COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities
- Medicine, Biology
The authors provide a foundation for cardiovascular and cardio-oncology physicians on the front line providing care to patients with COVID-19 to better understand the emerging cardiovascular epidemiology and the biological rationale for the clinical trials that are ongoing for the treatment of patients with CoV-19.
COVID-19 in Older People: A Rapid Clinical Review
- MedicineAge and ageing
A rapid review of the current and emergent evidence in the COVID-19 literature is provided to form a basis on which future work can be established and suggests social distancing policies could have important negative consequences.
Candidate drugs against SARS-CoV-2 and COVID-19
- Biology, ChemistryPharmacological Research
Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today's battle against COVID-19?
- Biology, MedicineMedical Hypotheses