WHO first international standards for prostate-specific antigen: the beginning of the end for assay discrepancies?

@article{Chan2000WHOFI,
  title={WHO first international standards for prostate-specific antigen: the beginning of the end for assay discrepancies?},
  author={Daniel Wai-Tin Chan and Lori Sokoll},
  journal={Clinical chemistry},
  year={2000},
  volume={46 9},
  pages={
          1291-2
        }
}
Despite the success of prostate-specific antigen (PSA) as a tumor marker for the early detection and monitoring of disease in prostate cancer, both clinical and analytical limitations of PSA remain (1 ). Since the introduction of assays for total PSA in the mid-1980s, assay results have been found to differ among manufacturers (2, 3). Much has been learned in the last two decades about the biology of PSA and the molecular forms of PSA present in serum. Differences among assays still persist… CONTINUE READING

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