WHIM syndrome, an autosomal dominant disorder: clinical, hematological, and molecular studies.

@article{Gorlin2000WHIMSA,
  title={WHIM syndrome, an autosomal dominant disorder: clinical, hematological, and molecular studies.},
  author={Robert J. Gorlin and Bruce S. Gelb and George A Diaz and K G Lofsness and Mark R. Pittelkow and John R Fenyk},
  journal={American journal of medical genetics},
  year={2000},
  volume={91 5},
  pages={368-76}
}
The acronym WHIM refers to Warts, Hypogammaglobulinemia, Infections, and Myelokathexis. The latter refers to the retention of white cells in the marrow, which becomes hypercellular. We have found approximately 20 examples of WHIM syndrome in the literature under various designations; the first examples are Zuelzer [1964] and Krill et al. [1964]. Chronic noncyclic neutropenia and hypercellular bone marrow represent defective release of marrow cells into the peripheral stream (myelokathexis). The… CONTINUE READING
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