WF-10129, a novel angiotensin converting enzyme inhibitor produced by a fungus, Doratomyces putredinis.

@article{Ando1987WF10129AN,
  title={WF-10129, a novel angiotensin converting enzyme inhibitor produced by a fungus, Doratomyces putredinis.},
  author={T. Ando and S. Okada and I. Uchida and K. Hemmi and M. Nishikawa and Y. Tsurumi and A. Fujie and K. Yoshida and M. Okuhara},
  journal={The Journal of antibiotics},
  year={1987},
  volume={40 4},
  pages={
          468-75
        }
}
  • T. Ando, S. Okada, +6 authors M. Okuhara
  • Published 1987
  • Chemistry, Medicine
  • The Journal of antibiotics
  • WF-10129 is an angiotensin converting enzyme (ACE) inhibitor produced by Doratomyces putredinis. IC50 of the compound is 1.4 X 10(-8) M for the ACE activity. WF-10129 was purified from cultured filtrate by successive ion exchange chromatography and HPLC. The chemical structure 1 was elucidated on the basis of spectroscopic and chemical evidence. The compound is a dipeptide composed of L-tyrosine and a novel amino acid. WF-10129 inhibits the pressor response of angiotensin I when administered… CONTINUE READING
    10 Citations
    Peptidomimetics derived from natural products
    • 169

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