WEB 2347: pharmacology of a new very potent and long acting hetrazepinoic PAF-antagonist and its action in repeatedly sensitized guinea-pigs.

@article{Heuer1991WEB2P,
  title={WEB 2347: pharmacology of a new very potent and long acting hetrazepinoic PAF-antagonist and its action in repeatedly sensitized guinea-pigs.},
  author={Hubert Otto Heuer},
  journal={Journal of lipid mediators},
  year={1991},
  volume={4 1},
  pages={39-44}
}
WEB 2347 is a new hetrazepine which is superior to the previously described paf-antagonists WEB 2086 (apafant) and WEB 2170 (bepafant). This refers to both potency in vitro and in vivo (particularly after oral administration: e.g. the ED50 after oral administration is about 100 times less for WEB 2347 than for WEB 2086 to antagonize paf-induced hypotension… CONTINUE READING