WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway

  title={WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway},
  author={C C Hsieh and Chih-Li Lin and Hsuan Liu and Y J Chang and Chii-Jiun Shih and Chang Zheng Zhong and Sheng-Chung Lee and Bertrand Chin-Ming Tan},
  booktitle={Nucleic acids research},
The centromere is a highly specialized chromosomal element that is essential for chromosome segregation during mitosis. Centromere integrity must therefore be properly preserved and is strictly dependent upon the establishment and maintenance of surrounding chromatin structure. Here we identify WDHD1, a WD40-domain and HMG-domain containing protein, as a key regulator of centromere function. We show that WDHD1 associates with centromeres in a cell cycle-dependent manner, coinciding with mid-to… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations


Publications referenced by this paper.
Showing 1-10 of 53 references

Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2010

Similar Papers

Loading similar papers…