WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.

@article{Hughes2008WAY200070AS,
  title={WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.},
  author={Zo{\"e} A. Hughes and Feng Liu and Brian J. Platt and Jason M. Dwyer and Claudine M Pulicicchio and Guoming Zhang and Lee E. Schechter and Sharon J Rosenzweig-Lipson and Mark S. Day},
  journal={Neuropharmacology},
  year={2008},
  volume={54 7},
  pages={1136-42}
}
Recent studies have reported that estrogen has antidepressant-like effects in animal models. In this study we used the highly selective ER beta agonist, WAY-200070, to examine the role of ER beta activation on brain neurochemistry and activity in antidepressant and anxiolytic models in male mice. Within 15 min of administration, WAY-200070 (30 mg/kg s.c.) caused the nuclear translocation of striatal ER beta receptors from the cytosol. WAY-200070 also increased c-fos activation 4h, but not 15… CONTINUE READING

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