WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D4 receptor activation

  title={WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D4 receptor activation},
  author={D. Marona-Lewicka and D. Nichols},
  journal={Behavioural Pharmacology},
  • D. Marona-Lewicka, D. Nichols
  • Published 2009
  • Chemistry, Medicine
  • Behavioural Pharmacology
  • In-vitro studies have shown that WAY 100635 is not only a potent 5-HT1A antagonist, but also has high affinity and efficacy at the dopamine D4 receptor. Nevertheless, the behavioral effects of this compound have not been investigated. This study sought to characterize the discriminative stimulus effects produced by WAY 100635. Male Sprague–Dawley rats were trained in a two-lever, fixed ratio 50, food-reinforced task with WAY 100635 (10 μmol/kg) as a discriminative stimulus. Substitution tests… CONTINUE READING
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