WAXS studies of the structural diversity of hemoglobin in solution.

  title={WAXS studies of the structural diversity of hemoglobin in solution.},
  author={Lee Makowski and J Bardhan and David Marcus Gore and Jyotsana Lal and Suneeta Mandava and S -J Park and Diane J. Rodi and Nancy T. Ho and Chien Ho and Robert F. Fischetti},
  journal={Journal of molecular biology},
  volume={408 5},
Specific ligation states of hemoglobin are, when crystallized, capable of taking on multiple quaternary structures. The relationship between these structures, captured in crystal lattices, and hemoglobin structure in solution remains uncertain. Wide-angle X-ray solution scattering (WAXS) is a sensitive probe of protein structure in solution that can distinguish among similar structures and has the potential to contribute to these issues. We used WAXS to assess the relationships among the… CONTINUE READING

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