WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression.

@article{SosseyAlaoui2005WAVE3PC,
  title={WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression.},
  author={Khalid Sossey-Alaoui and Tamara A. Ranalli and Xiurong Li and Andrei V Bakin and John K Cowell},
  journal={Experimental cell research},
  year={2005},
  volume={308 1},
  pages={135-45}
}
WAVE3 is a member of the WASP/WAVE family of proteins, which play a critical role in the regulation of actin polymerization, cytoskeleton organization, and cell motility. We show here that knockdown of the WAVE3 protein, using RNA interference in MDA-MB-231 cells, decreases phospho-p38 MAPK levels, but not those of phospho-AKT, phospho-ERK, or phospho-JNK. Knockdown of WAVE3 expression also inhibited the expression levels of MMP-1, MMP-3, and MMP-9, but not MMP-2. MMP production could be… CONTINUE READING

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