WAVE3-NFκB Interplay Is Essential for the Survival and Invasion of Cancer Cells

@inproceedings{Davuluri2014WAVE3NFBII,
  title={WAVE3-NFκB Interplay Is Essential for the Survival and Invasion of Cancer Cells},
  author={Gangarao Davuluri and Katarzyna Augoff and William P. Schiemann and Edward F Plow and Khalid Sossey-Alaoui and Chengfeng Yang},
  booktitle={PloS one},
  year={2014}
}
The WAVE3 cytoskeletal protein promotes cancer invasion and metastasis. We have shown that the WAVE3-mediated activation of cancer cell invasion is due, in part, to its regulation of expression and activity of key metalloproteinases (MMPs), including MMP9, which is centrally involved in invadopodia-mediated degradation of the extracellular matrix (ECM). MMP9 is also a major NFκB target gene, suggesting a potential linkage of WAVE3 to this pathway, which we sought to investigate. Mechanistically… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

NF-kappaB and cancer-identifying targets and mechanisms.

  • Current opinion in genetics & development
  • 2008
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Matrix metalloproteinases and tumor metastasis

  • Cancer and Metastasis Reviews
  • 2006
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014