WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.

@article{Snapper2005WASPDL,
  title={WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.},
  author={Scott B. Snapper and Parool Meelu and Deanna Nguyen and Britt M. Stockton and Patr{\'i}cia Torres Bozza and Frederick W Alt and Fred S. Rosen and Ulrich H von Andrian and Christoph Klein},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={77 6},
  pages={993-8}
}
Intact cellular migration is critically important for the induction and regulation of the immune response. The Wiskott-Aldrich syndrome protein (WASP) regulates surface receptor signaling to the actin cytoskeleton in hematopoietic cells and thus plays a pivotal role in cellular locomotion. WASP deficiency causes the Wiskott-Aldrich syndrome (WAS), characterized by immunodeficiency, thrombocytopenia, and eczema. Cell migration defects may contribute to the pathophysiology of WAS. In this study… CONTINUE READING