WASP: a key immunological multitasker

  title={WASP: a key immunological multitasker},
  author={Adrian J. Thrasher and Siobhan O. Burns},
  journal={Nature Reviews Immunology},
The Wiskott–Aldrich syndrome protein (WASP) is an important regulator of the actin cytoskeleton that is required for many haematopoietic and immune cell functions, including effective migration, phagocytosis and immune synapse formation. Loss of WASP activity leads to Wiskott–Aldrich syndrome, an X-linked disease that is associated with defects in a broad range of cellular processes, resulting in complex immunodeficiency, autoimmunity and microthrombocytopenia. Intriguingly, gain of function… CONTINUE READING
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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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