• Corpus ID: 44045914

WAND: A 128-channel, closed-loop, wireless artifact-free neuromodulation device

@article{Zhou2017WANDA1,
  title={WAND: A 128-channel, closed-loop, wireless artifact-free neuromodulation device},
  author={Andy Zhou and Samantha R. Santacruz and Benjamin C. Johnson and George Alexandrov and Ali Moin and Fred L. Burghardt and Jan M. Rabaey and Jose M. Carmena and Rikky Muller},
  journal={arXiv: Neurons and Cognition},
  year={2017}
}
Closed-loop neuromodulation systems aim to treat a variety of neurological conditions by dynamically delivering and adjusting therapeutic electrical stimulation in response to a patient's neural state, recorded in real-time. Existing systems are limited by low channel counts, lack of algorithmic flexibility, and distortion of recorded signals from large, persistent stimulation artifacts. Here, we describe a device that enables new research applications requiring high-throughput data streaming… 
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References

SHOWING 1-10 OF 94 REFERENCES

A Fully Self-Contained Logarithmic Closed-Loop Deep Brain Stimulation SoC With Wireless Telemetry and Wireless Power Management

A logarithmic, closed-loop DBS system that detects and processes low-frequency brain field signals to control and adapt stimulation currents and achieves high dynamic range is introduced.

Toward true closed-loop neuromodulation: artifact-free recording during stimulation

Battery-less Tri-band-Radio Neuro-monitor and Responsive Neurostimulator for Diagnostics and Treatment of Neurological Disorders

Efficacy of the SoC is assessed using a rat model of temporal lobe epilepsy characterized by spontaneous seizures, which exhibits an average seizure detection sensitivity and specificity of 87% and 95%, respectively, with over 78% of all seizures aborted.

Design and Validation of a Fully Implantable, Chronic, Closed-Loop Neuromodulation Device With Concurrent Sensing and Stimulation

Systematic methods to mitigate the effect of stimulation through a combination of sensing hardware, stimulation parameter selection, and classification algorithms that counter residual stimulation disturbances are described.

The PennBMBI: A general purpose wireless Brain-Machine-Brain Interface system for unrestrained animals

A general purpose wireless Brain-Machine-Brain Interface (BMBI) system that integrates a neural signal analyzer, two neural stimulators with different specifications, multiple body area sensory devices and a user-friendly computer interface is proposed.

64-Channel UWB Wireless Neural Vector Analyzer SOC With a Closed-Loop Phase Synchrony-Triggered Neurostimulator

An ultra wideband (UWB) 64-channel responsive neural stimulator system-on-chip (SoC) is presented, which is validated in the early detection and abortion of seizures in freely moving rodents on-line and in early seizure detection in humans off-line.

A Low-Power Integrated Circuit for a Wireless 100-Electrode Neural Recording System

A prototype integrated circuit for wireless neural recording from a 100-channel microelectrode array was developed and a two-chip system was used to record neural signals from a Utah Electrode Array in cat cortex and transmit the digitized signals wirelessly to a receiver.

A fully integrated closed-loop neuromodulation SoC with wireless power and bi-directional data telemetry for real-time human epileptic seizure control

A 16-channel closed-loop neuromodulation SoC for human seizure control that includes a 16-ch signal acquisition unit, a bio-signal processor, a16-ch adaptive stimulator, and wireless telemetry is presented.

Design of Ultra-Low Power Biopotential Amplifiers for Biosignal Acquisition Applications

A closed-loop complementary-input amplifier, which has a bandwidth of 0.05 Hz to 10.5 kHz, an input-referred noise of 2.2 μ Vrms, and a power dissipation of 12 μW, is introduced.

A ±50-mV Linear-Input-Range VCO-Based Neural-Recording Front-End With Digital Nonlinearity Correction

A neural-recording front-end that has an input range of ±50 mV and can be used in closed-loop systems and avoids the saturation due to stimulation artifacts by employing a voltage-controlled oscillator (VCO) to directly convert the input signal into the frequency domain.
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