WAF1, a potential mediator of p53 tumor suppression.

  title={WAF1, a potential mediator of p53 tumor suppression.},
  author={Wafik S El-Deiry and Takashi Tokino and Victor E. Velculescu and Daniel B. Levy and Ramon E. Parsons and Jeffrey M. Trent and Danjuan Lin and W. Edward Mercer and Kenneth W. Kinzler and Bert Vogelstein},
  volume={75 4},
The ability of p53 to activate transcription from specific sequences suggests that genes induced by p53 may mediate its biological role as a tumor suppressor. Using a subtractive hybridization approach, we identified a gene, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line. The WAF1 gene was localized to chromosome 6p21.2, and its sequence, structure, and activation by p53 was conserved in rodents. Introduction of WAF1… CONTINUE READING
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