WAF 1 / CIP 1 Expression is Differentially Regulated by Metformin and Rapamycin

@inproceedings{Molnr2014WAF1,
  title={WAF 1 / CIP 1 Expression is Differentially Regulated by Metformin and Rapamycin},
  author={Zolt{\'a}n Moln{\'a}r and Ann B. Millward and Wai Fong Tse and Andrew Glen Demaine},
  year={2014}
}
The mammalian target of rapamycin (mTOR) pathway plays an important role in the development of diabetic nephropathy and other age-related diseases. One of the features of DN is the elevated expression of p21WAF1/CIP1. However, the importance of the mTOR signalling pathway in p21 regulation is poorly understood. Here we investigated the effect of metformin and rapamycin on mTOR-related phenotypes in cell lines of epithelial origin. This study reports that metformin inhibits high glucose-induced… CONTINUE READING