W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.

@article{Reith1990WMM,
  title={W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.},
  author={Alastair D. Reith and Robert Rottapel and E B Giddens and Catherine Brady and Lesley Forrester and Alan Bernstein},
  journal={Genes & development},
  year={1990},
  volume={4 3},
  pages={390-400}
}
Mutations at the mouse W/c-kit locus lead to intrinsic defects in stem cells of the melanocytic, hematopoietic, and germ cell lineages. W alleles vary in the overall severity of phenotype that they confer, and some alleles exhibit an independence of pleiotropic effects. To elucidate the molecular basis for these biological differences, we analyzed the c-kit locus and the c-kit-associated autophosphorylation activities in five different W mutants representative of a range of W phenotypes. Mast… CONTINUE READING

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