Vulvar Seborrheic Keratosis: Is There a Relationship to Human Papillomavirus?
@article{Reutter2014VulvarSK, title={Vulvar Seborrheic Keratosis: Is There a Relationship to Human Papillomavirus?}, author={Jason C. Reutter and Kim R. Geisinger and Jennifer Laudadio}, journal={Journal of Lower Genital Tract Disease}, year={2014}, volume={18}, pages={190–194} }
OBJECTIVE
We sought to determine the prevalence of human papillomavirus (HPV) subtypes in vulvar seborrheic keratoses (SK) by polymerase chain reaction (PCR) in women with a theoretically low risk of recent HPV transmission. [] Key MethodMETHODS
Twenty-eight cases of vulvar SK in women older than 50 years old were retrospectively pulled from our files from a 7-year period.
14 Citations
Recent advances in managing and understanding seborrheic keratosis
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- 2019
Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma.
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Given the morphologic overlap and biological equivalence of HPV-related preinvasive squamous lesions of the lower anogenital tract, a unified, 2-tiered histopathologic nomenclature is now recommended.
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The association in this case with a low-risk HPV type, HPV 42, provides further evidence for a role of this HPV type in the pathogenesis of these lesions.
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A clinical audit of 194 cases and review of the literature found Vulvar psoriasis in adults and children with recurrent vulvovaginal candidosis to be the most common cause of symptomatic vulvar disease.
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- MedicineJournal of lower genital tract disease
- 2015
A clinical audit of 194 cases and review of the literature found Vulvar psoriasis in adults and children with recurrent vulvovaginal candidosis to be the most common cause of symptomatic vulvar disease.
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Recognition of relatively rare entities such as bowenoid papulosis, epidermolytic acanthoma, and verruciform xanthoma would avoid overdiagnosis and unnecessary, overaggressive treatment.
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- MedicineOpen access Macedonian journal of medical sciences
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The classical treatment options for Seborrheic keratoses are cryotherapy and curettage, and topical treatment with 40% hydrogen peroxide and the nitric-zinc complex has been investigated.
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Management of HPV and HSV infections involves appropriate counseling, screening, and multiple treatment techniques, and a practitioner may need to use a combination of techniques to achieve the desired outcome.
Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses
- MedicineDermatology
- 2021
Advances in molecular pathogenesis suggest that inhibition of Akt and APP, as well as existing treatments for skin cancer, may have therapeutic potential in SK, and promising alternatives, such as nitric-zinc and trichloroacetic acid topicals, should be further developed.
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