Vulvar Seborrheic Keratosis: Is There a Relationship to Human Papillomavirus?

@article{Reutter2014VulvarSK,
  title={Vulvar Seborrheic Keratosis: Is There a Relationship to Human Papillomavirus?},
  author={Jason C. Reutter and Kim R. Geisinger and Jennifer Laudadio},
  journal={Journal of Lower Genital Tract Disease},
  year={2014},
  volume={18},
  pages={190–194}
}
OBJECTIVE We sought to determine the prevalence of human papillomavirus (HPV) subtypes in vulvar seborrheic keratoses (SK) by polymerase chain reaction (PCR) in women with a theoretically low risk of recent HPV transmission. [] Key MethodMETHODS Twenty-eight cases of vulvar SK in women older than 50 years old were retrospectively pulled from our files from a 7-year period.
Recent advances in managing and understanding seborrheic keratosis
TLDR
Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma.
Vulvar and Anal Intraepithelial Neoplasia: Terminology, Diagnosis, and Ancillary Studies.
TLDR
Given the morphologic overlap and biological equivalence of HPV-related preinvasive squamous lesions of the lower anogenital tract, a unified, 2-tiered histopathologic nomenclature is now recommended.
Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion
TLDR
The association in this case with a low-risk HPV type, HPV 42, provides further evidence for a role of this HPV type in the pathogenesis of these lesions.
Response to "Vulvar seborrheic keratosis and human papillomavirus".
TLDR
A clinical audit of 194 cases and review of the literature found Vulvar psoriasis in adults and children with recurrent vulvovaginal candidosis to be the most common cause of symptomatic vulvar disease.
Vulvar seborrheic keratosis and human papillomavirus.
TLDR
A clinical audit of 194 cases and review of the literature found Vulvar psoriasis in adults and children with recurrent vulvovaginal candidosis to be the most common cause of symptomatic vulvar disease.
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region.
  • M. Chan
  • Medicine
    Archives of pathology & laboratory medicine
  • 2019
TLDR
Recognition of relatively rare entities such as bowenoid papulosis, epidermolytic acanthoma, and verruciform xanthoma would avoid overdiagnosis and unnecessary, overaggressive treatment.
Seborrheic Keratoses – The Most Common Benign Skin Tumor of Humans. Clinical presentation and an update on pathogenesis and treatment options
  • U. Wollina
  • Medicine
    Open access Macedonian journal of medical sciences
  • 2018
TLDR
The classical treatment options for Seborrheic keratoses are cryotherapy and curettage, and topical treatment with 40% hydrogen peroxide and the nitric-zinc complex has been investigated.
Viral Venereal Diseases of the Skin
TLDR
Management of HPV and HSV infections involves appropriate counseling, screening, and multiple treatment techniques, and a practitioner may need to use a combination of techniques to achieve the desired outcome.
Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses
TLDR
Advances in molecular pathogenesis suggest that inhibition of Akt and APP, as well as existing treatments for skin cancer, may have therapeutic potential in SK, and promising alternatives, such as nitric-zinc and trichloroacetic acid topicals, should be further developed.
...
...

References

SHOWING 1-10 OF 14 REFERENCES
Seborrheic keratoses from the genital region may contain human papillomavirus DNA.
TLDR
It is concluded that human papillomavirus infection cannot be excluded in genital seborrheic keratosis-like lesions from the genital region.
Development and duration of human papillomavirus lesions, after initial infection.
TLDR
Intraepithelial lesions are common early events among women with incident HPV infection, and the interval between incident HPV-16 or HPV-18 infection and biopsy-confirmed CIN grade 2-3 appears to be relatively short.
"Seborrheic keratoses" that contain human papillomavirus are condylomata acuminata.
TLDR
It is concluded that lesions said to be seborrheic keratoses replete with HPV are really condylomata acuminata, and this essay gives reasons for this conclusion.
Natural history of cervicovaginal papillomavirus infection in young women.
TLDR
The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
Detection of Human Papillomavirus Types 6 and 11 in Pubic and Perianal Hair from Patients with Genital Warts
TLDR
The presence of genital HPV types in plucked pubic and perianal hair suggests that there is an endogenous reservoir for HPV which may play a role in the recurrences of genital warts.
Persistence of genital human papillomavirus infection in a long-term follow-up study of female university students.
TLDR
HPV variant and behavioral risk factor analyses indicated that long-term detection of the same HPV type was more consistent with viral persistence than with reinfection, and it was associated with detection of HPV-related pathologies.
Persistent HPV infection in postmenopausal age women
  • E. Smith, S. R. Johnson, T. Haugen
  • Medicine, Biology
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2004
...
...