Vulvar Lichen Sclerosus

@article{Smith2004VulvarLS,
  title={Vulvar Lichen Sclerosus},
  author={Yolanda R. Smith and Hope K. Haefner},
  journal={American Journal of Clinical Dermatology},
  year={2004},
  volume={5},
  pages={105-125}
}
AbstractLichen sclerosus is a chronic disorder of the skin and mucosal surfaces, and is most commonly seen on the female genital skin. It also occurs on other areas of the body. Any age group may be affected, although it is seen more often in elderly women. The exact cause of lichen sclerosus is unknown. There have been reports of family members with lichen sclerosus; thus it may have a genetic link. There is also the possibility of an autoimmune connection. Currently, ultra-potent topical… Expand
[Lichen sclerosus].
TLDR
Lichen sclerosus is a chronic disorder of skin and mucosa which affects patients of all age groups, particularly women, but also men and is characterised by remissions and exacerbations. Expand
Lichen sclerosus of the vulva
TLDR
Chronic and severe vulvar itching, especially at night, is the predominant symptom reported by almost all patients, and diagnosis is often delayed by long-term self-administered topical preparations, or by the clinician’s unawareness of the disease. Expand
Lichen sclerosus of the vulva and squamous cell carcinoma
TLDR
The need for a thorough clinical and histopathological follow-up of patients with genital lichen sclerosus with a frequent disease that should be assessed jointly by dermatologists and gynecologists is justified. Expand
Diagnosis and Treatment of Lichen Sclerosus An Update
Lichen sclerosus (LS) is a chronic, inflammatory, mucocutaneous disorder of genital and extragenital skin. LS is a debilitating disease, causing itch, pain, dysuria and restriction of micturition,Expand
Vulvar lichen sclerosus, premalign inflammatory dermatosis
TLDR
It is of foremost importance to diagnose VLS in an early stage, to closely follow up with the gynecologist and dermatologist, while carefully and steadily monitoring these lesions and to initiate the appropriate disease-specific treatment. Expand
Non-neoplastic epithelial disorders of the vulva.
TLDR
Patients with lichen sclerosus, lichen planus, and lichen simplex chronicus are three of the most common non-neoplastic epithelial disorders of the vulva and educational counseling teaches patients that even though these chronic disorders cannot be cured, they can be effectively managed. Expand
Vulvar Lichen Sclerosus in the Elderly
TLDR
Treatment is important and the regimen most often includes topical corticosteroid ointments, and lifetime surveillance of the skin is imperative because of the increased risk of squamous cell carcinoma in patients with lichen sclerosus. Expand
Non-Neoplastic Epithelial Disorders of the Vulva
TLDR
Patients with lichen sclerosus, lichen planus, and lichen simplex chronicus are three of the most common non-neoplastic epithelial disorders of the vulva and educational counseling teaches patients that even though these chronic disorders cannot be cured, they can be effectively managed. Expand
Lichen Sclerosus in a Breast Cancer Survivor on an Aromatase Inhibitor: A Case Report
TLDR
It is proposed that all patients prescribed aromatase inhibitors undergo regular vulvo-vaginal exams to rule out lichen sclerosus and other hypoestrogen-related vulvo/vaginal problems. Expand
Lichen Sclerosus: Subdermal Steroid Injection Therapy. A Large, Long-Term Follow-Up Study
TLDR
The aim of this long-term study was to quantify the termination of pruritus, reduction of active disease progression, and cessation of scarring in response to a program of subdermal steroid injection regimen for LS. Expand
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TLDR
Surgical treatment of lichen sclerosus of the vulva is suitable only for patients who failed to respond to multiple medical treatments such as topical high potent steroid ointments, testosterone, and retinoids. Expand
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TLDR
Lichen sclerosus is a skin condition affecting all areas of the body at all ages and in both sexes and its predilection for the anogenital area in women has led to an unfortunate dichotomy between dermatologists and gynecologists. Expand
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TLDR
Although the cause of LS remains uncertain, it is not a rare disease in prepubertal girls and current optimal management includes prompt diagnosis and institution of treatment with a potent topical steroid. Expand
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TLDR
Ccinoma of the vulva supervened in only 4 women in this series and that at 7 months, 3 years, 4½ years, and 10 years after the patient was first seen, which is an indication for vulvectomy although the operation does not necessarily protect the woman from cancer. Expand
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TLDR
Lichen sclerosus is a chronic skin disease manifesting itself mostly in the perineal region and often associated with itching, with well-defined depigmentation and degeneration of the skin sometimes showing haemorrhagic bullae or teleangiectases. Expand
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TLDR
The topical application of cyclosporine could avoid the systemic side effects of the drug, making possible its use for localized immunomediated dermatoses, including vulvar lichen sclerosus and mucosal lichen planus. Expand
Relation of lichen sclerosus et atrophicus of the vulva to development of carcinoma.
TLDR
This study did not provide evidence of carcinoma arising from LS&A, but five of the 92 patients developed 6 malignant neoplasms in other sites, including carcinoma of the endometrium, lung, and simultaneous carcinomas of the colon and cervix. Expand
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TLDR
Two patients with lichen sclerosus of the vulva in pregnancy are reported, with emphasis on the diagnosis and treatment of this condition. Expand
A study of clinical and aetiological factors and possible associations of lichen sclerosus in males
TLDR
The findings indicate that lichen sclerosus in males exists as a spectrum of disease, ranging from a mild form with white plaques and few symptoms to a severe form with inflammation, atrophy and scarring with possible urological consequences. Expand
Squamous cell carcinoma arising in vulval lichen sclerosus: a longitudinal cohort study
TLDR
Data support the view that LS is a precursor of SCC, although characterized by slight tendency to evolve to carcinoma, and medical treatment of LS, although useful in the control of severity of disease, did not seem to be able to prevent the evolution to malignancy. Expand
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