Vulnerability of select neuronal types to Alzheimer's disease.

@article{Braak2000VulnerabilityOS,
  title={Vulnerability of select neuronal types to Alzheimer's disease.},
  author={Heiko Braak and Kelly del Tredici and Christian Schultz and Eva Braak},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={924},
  pages={
          53-61
        }
}
From a morphological perspective, Alzheimer's disease (AD) is primarily a degenerative disorder of the neuronal cytoskeleton involving lipofuscin-laden cortical projection neurons with long, thin, and sparsely myelinated axons. The neocortical primary fields, relatively small in extent but functionally sophisticated, exhibit an early and brief myelination cycle, whereas the much more expansive but relatively simply organized association areas undergo a late and prolonged myelination process… CONTINUE READING

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