Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice.


BACKGROUND Examination of the in vivo activation and function of CD4+ T cells in response to allografts may advance our understanding of the rejection process. We analyzed the capacity of transgenic class II-restricted CD4 T cells to reject skin, cardiac, and islet transplants. METHODS TS1 mice possess a high frequency of CD4+ T cells specific for the… (More)


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