Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone exposure.

@article{Korade2017VulnerabilityOD,
  title={Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone exposure.},
  author={Željka Korade and Thiago C. Genaro-Mattos and Keri A. Tallman and Wei Liu and Krassimira A. Garbett and Katalin Koczok and Istv{\'a}n Balogh and Karoly Mirnics and Ned A. Porter},
  journal={Journal of lipid research},
  year={2017},
  volume={58 11},
  pages={
          2139-2146
        }
}
Smith-Lemli-Opitz syndrome is a recessive disorder caused by mutations in 7-dehydrocholesterol reductase (DHCR)7 with a heterozygous (HET) carrier frequency of 1-3%. A defective DHCR7 causes accumulation of 7-dehydrocholesterol (DHC), which is a highly oxidizable and toxic compound. Recent studies suggest that several antipsychotics, including the highly… CONTINUE READING