Vulnerabilities of mutant SWI/SNF complexes in cancer.


Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typically loss-of-function mutations and not… (More)
DOI: 10.1016/j.ccr.2014.07.018


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