VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity.

@article{Popella2016VraHIT,
  title={VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity.},
  author={Peter Popella and Sophia Krauss and Patrick Ebner and Mulugeta Nega and Julia Deibert and Friedrich G{\"o}tz},
  journal={Antimicrobial agents and chemotherapy},
  year={2016},
  volume={60 4},
  pages={2391-401}
}
In bacteria, extracellular signals are transduced into the cell predominantly by two-component systems (TCSs) comprising a regulatory unit triggered by a specific signal. Some of the TCSs control executing units such as ABC transporters involved in antibiotic resistance. For instance, inStaphylococcus aureus, activation of BraSR leads to the upregulation ofvraDEexpression that encodes an ABC transporter playing a role in bacitracin and nisin resistance. In this study, we show that the small… CONTINUE READING
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