Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages.

@article{Fujita2008VpxIC,
  title={Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages.},
  author={Mikako Fujita and M. Otsuka and Masami Miyoshi and Boonruang Khamsri and Masako Nomaguchi and Akio Adachi},
  journal={Journal of virology},
  year={2008},
  volume={82 15},
  pages={7752-6}
}
The abilities of wild-type and vpx-defective human immunodeficiency virus type 2 (HIV-2) clones to synthesize viral DNA in human monocyte-derived macrophages (MDMs) and lymphocytic cells were comparatively and quantitatively evaluated. While the vpx-defective mutant directed the synthesis of viral DNA comparably to the wild-type virus and normally in lymphocytic cells, no appreciable viral DNA was detected in MDMs infected with the mutant. To substantiate this finding and to determine whether… CONTINUE READING