Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains.

@article{Gomez2005VpumediatedCD,
  title={Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains.},
  author={L. Maroto Gomez and Erik Pacyniak and Melissa Flick and David R. Hout and Marwilio Sanchez Gomez and Eric Nerrienet and Ahidjo Ayouba and Mario L Santiago and Beatrice H. Hahn and Edward B. Stephens},
  journal={Virology},
  year={2005},
  volume={335 1},
  pages={
          46-60
        }
}
Human immunodeficiency virus type 1 (HIV-1) along with simian immunodeficiency viruses from chimpanzees (SIV(cpz)) and three species of Old World monkeys from the genus Cercopithecus have been shown to encode a Vpu protein. To date, the functional characterization of Vpu has been limited to a small number of subtype B and more recently subtype C Vpu proteins. Using a recently developed VpuEGFP reporter system, we have shown that the subtype B and C Vpus are capable of preventing CD4 from being… CONTINUE READING
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