Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

@article{Mitchell2009VpuAB,
  title={Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking},
  author={R. S. Mitchell and Chris Katsura and Mark A. Skasko and Katie F. Fitzpatrick and David T. W. Lau and Autumn Ruiz and Edward B. Stephens and Florence Margottin-Goguet and Richard Benarous and John Guatelli},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={388 - 398}
}
The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells. The HIV-1 accessory protein Vpu antagonizes this restriction by an unknown mechanism that likely involves the down-regulation of BST-2 from the cell surface. Here, we show that the optimal removal of BST-2 from the plasma membrane by Vpu requires the cellular protein beta-TrCP, a substrate adaptor for a multi-subunit SCF E3 ubiquitin ligase complex and a… CONTINUE READING
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