Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation.

@article{Bryant2001Vps45pST,
  title={Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation.},
  author={Nia J. Bryant and David E. James},
  journal={The EMBO journal},
  year={2001},
  volume={20 13},
  pages={3380-8}
}
Sec1p-like/Munc-18 (SM) proteins bind to t-SNAREs and inhibit ternary complex formation. Paradoxically, the absence of SM proteins does not result in constitutive membrane fusion. Here, we show that in yeast cells lacking the SM protein Vps45p, the t-SNARE Tlg2p is down-regulated, to undetectable levels, by rapid proteasomal degradation. In the absence of… CONTINUE READING