Vps33a mediates RANKL storage in secretory lysosomes in osteoblastic cells.

@article{Kariya2009Vps33aMR,
  title={Vps33a mediates RANKL storage in secretory lysosomes in osteoblastic cells.},
  author={Yoshiaki Kariya and Masashi Honma and Shigeki Aoki and Atsushi Chiba and Hiroshi Kubiki Suzuki},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2009},
  volume={24 10},
  pages={
          1741-52
        }
}
Previous studies have indicated that the amount of RANKL expressed on the cell surface of osteoblasts or bone marrow stromal cells (BMSCs) is considered an important factor determining the extent of osteoclast activation. However, subcellular trafficking of RANKL and its regulatory mechanisms in osteoblastic cells is still unclear. In this study, we showed that RANKL is predominantly localized in lysosomal organelles, but little is found on the cell surface of osteoblastic cells. We also showed… CONTINUE READING
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General Discussion

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